GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs60843830 | 1 | rs2126129 | chr2:212548 | SH3YL1 | chr2:218138-264810:- | -0.47 | -6.34 | 2.52E-9 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs9815354 | 1 | rs2128834 | chr3:41862645 | ULK4 | chr3:41288091-42003660:- | 0.47 | 5.45 | 1.96E-7 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs2128835 | chr3:41862873 | ULK4 | chr3:41288091-42003660:- | 0.45 | 5.21 | 6.03E-7 | Diastolic blood pressure |
| UCEC | cis | rs2130392 | 1 | rs2130392 | chr4:185639169 | MLF1IP | chr4:185615220-185655286:- | -0.51 | -8.32 | 4.6E-14 | Kawasaki disease |
| UCEC | cis | rs9309473 | 1 | rs2140195 | chr2:73702344 | ALMS1P | chr2:73872046-73912692:+ | 0.5 | 5.91 | 2.12E-8 | Metabolite levels |
| UCEC | cis | rs2241437 | 1 | rs2164879 | chr2:86261579 | LOC90784 | chr2:86247339-86250991:- | -0.69 | -6.44 | 1.51E-9 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| UCEC | cis | rs1577917 | 1 | rs2166663 | chr6:86593896 | SNHG5 | chr6:86386726-86388451:- | -0.45 | -5.74 | 4.91E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs7528684 | 1 | rs2210913 | chr1:157668993 | FCRL3 | chr1:157646278-157670775:- | 0.38 | 6.1 | 8.58E-9 | Type 1 diabetes autoantibodies |
| UCEC | cis | rs763014 | 1 | rs2269558 | chr16:682250 | WFIKKN1 | chr16:679239-684116:+ | 0.45 | 5.6 | 9.59E-8 | Height |
| UCEC | cis | rs9815354 | 1 | rs2272006 | chr3:41997059 | ULK4 | chr3:41288091-42003660:- | -0.51 | -6.12 | 7.79E-9 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs2272007 | chr3:41996136 | ULK4 | chr3:41288091-42003660:- | -0.5 | -5.85 | 2.96E-8 | Diastolic blood pressure |
| UCEC | cis | rs60843830 | 1 | rs2290911 | chr2:224919 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.55 | 8.55E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs2294008 | 1 | rs2294010 | chr8:143762430 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.08 | 1.1E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs1577917 | 1 | rs2324843 | chr6:86617501 | SNHG5 | chr6:86386726-86388451:- | -0.52 | -5.88 | 2.51E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs2028299 | 1 | rs2351706 | chr15:90384115 | AP3S2 | chr15:90373832-90456222:- | -0.51 | -5.05 | 1.26E-6 | Type 2 diabetes |